The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may bring about a rise in methadone plasma concentrations, which could result in perhaps fatal respiratory melancholy. Furthermore, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also bring about a rise in m